Photodynamic
Therapy (PDT)
FDA-approved treatment for actinic keratoses and acne using Levulan® (aminolevulinic acid) and BLU-U® blue light — a non-invasive way to treat pre-skin cancer across large areas at once.
About PDT
What Is Photodynamic Therapy?
Photodynamic therapy is a two-step procedure that uses a photosensitizing drug (Levulan®) and visible blue light (BLU-U®) to selectively destroy abnormal cells — including precancerous actinic keratoses and acne-causing bacteria.
Unlike traditional spot treatments, PDT treats the entire affected area (field therapy), making it ideal for patients with widespread sun damage or multiple actinic keratoses that would otherwise require dozens of freeze treatments.
The treatment has a strong safety record and is FDA-approved for actinic keratoses. Many patients also see improvement in overall skin texture, tone, and pore size as a secondary benefit.
Conditions Treated
- Actinic keratoses (AKs) — precancerous lesions
- Superficial basal cell carcinoma
- Acne vulgaris (moderate to severe)
- Photo-damaged skin / sun spots
- Sebaceous gland hyperplasia
Key Facts
Treatment Protocol
How PDT Works
Preparation
~30 minutes
The target area is cleansed and lightly abraded to improve absorption. Levulan® (aminolevulinic acid) solution is applied to the skin.
Incubation
1 to 3 hours
Levulan® penetrates the abnormal cells and converts to a photosensitizing agent. You wait comfortably at the office — no light exposure during this phase.
Light Activation
16 minutes 40 seconds
The BLU-U® blue light device is applied. The light activates Levulan® and destroys the precancerous cells with minimal damage to surrounding tissue.
After Treatment
Recovery Timeline
PDT requires sun avoidance for at least 48 hours following treatment. The peeling and redness are normal — they're signs the treatment is working.
Day 1–2
Redness, swelling, and peeling are normal and expected. Avoid direct sunlight completely.
Day 3–5
Skin begins to peel and crust — do not pick. Continue sun avoidance and gentle moisturization.
Week 2
Most peeling resolves. New skin is sensitive. Broad-spectrum SPF 30+ is essential during this period.
Week 4–6
Follow-up visit to assess response. A second treatment may be recommended for optimal clearance.
FAQs
Common Questions
Does PDT hurt?
Most patients experience stinging or burning during light activation — similar to a sunburn. The sensation peaks during treatment and resolves quickly after the light is removed. We provide topical numbing and cooling fans to improve comfort.
How many treatments do I need?
One PDT session clears most actinic keratoses. Your dermatology professional may recommend a second session 4–6 weeks later for more extensive field damage or acne.
Will my insurance cover PDT?
PDT for actinic keratoses is covered by most insurance plans when medically necessary. Cosmetic applications (acne, photo-rejuvenation) are typically not covered. We verify coverage before your appointment.
Is PDT only available at one location?
Currently, PDT with Levulan® and BLU-U® is available exclusively at our Fort Myers office. Call us to schedule.
Schedule a PDT Consultation
Available at our Fort Myers office. Call to schedule a consultation with a dermatology professional who will evaluate whether PDT is right for you.
Insurance verification included before your appointment.